Serum irisin levels and osteoporosis in patients with advanced chronic kidney disease and renal transplant recipients

Demir, Canan
Dursun, Ali Doğan
Sarıyıldız, Gülçin Türkmen
Arslan, Aykut İlker
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International Urology and Nephrology
Aim To elucidate the association of serum irisin levels with bone mineral density (BMD) and calcium–phosphorus metabolism parameters in chronic kidney disease (CKD) patients and renal transplant recipients (RTRs). Methods This is a cross-sectional study involving CKD patients and RTRs. Healthy volunteers served as controls. Age, gender, and dialysis vintage were recorded. Serum irisin, creatinine, glucose, calcium, albumin, 25(OH) vitamin D, ferritin, C-reactive protein, A1C, and lipid profile were studied in all participants. Estimated glomerular filtration rate (eGFR), corrected calcium, and body mass index (BMI) were calculated. Results Overall, 49 patients (23 hemodialysis, 26 RTRs) and 25 control subjects were included. In hemodialysis (HD) group, 8 patients (34.8%) had osteoporosis, and 12 patients (52.2%) had osteopenia. In RTR group, 3 patients (11.5%) had osteoporosis, while 15 patients (57.7%) had osteopenia. Among controls, one had osteoporosis, and 7 had osteopenia. There was no significant difference between HD and RTRs; however, osteoporosis rate was significantly lower in control subjects. BMD measurements (femur and lumbar T- and Z-scores) were comparable between HD and RTR groups. Control group DEXA values were similar to RTRs; however, they were significantly higher compared to HD group. 25(OH) vitamin D levels were comparable between the HD and RTR groups, and these were significantly lower compared to values of the control group. Mean serum irisin level was 426.6 ± 191.2 pg/mL in hemodialysis group, 342.6 ± 174.8 in the RTR group, and 208.0 ± 186.1 in controls. Serum irisin levels were similar in RTR and HD groups, but their values were significantly higher compared to controls. When we compared serum irisin levels between patients with and without osteoporosis in the whole cohort and hemodialysis and RTR groups, there was no difference. Serum irisin was positively correlated with lumbar T-score both in hemodialysis and RTR groups. Conclusion Our study is the first in the literature revealing the positive correlation of serum irisin level with femur T-score in RTRs. Serum irisin level was also positively correlated with femur T-scores in hemodialysis patients.
Open Access, Published by International Urology and Nephrology,, Canan Demir, Department of Endocrinology and Metabolism, Atılım Üniversitesi Tıp Fakültesi, Kızılcaşarİncek Gölbaşı, 06830, Ankara, Turkey, Ali Doğan Dursun, Department of Physiology, Medical School, Atilim University, and Vocational School of Health Services, Atilim University, Ankara, Turkey, Gülçin Türkmen Sarıyıldız, Department of General Surgery, Medicana International Ankara Hospital, and Operating Room Services, Vocational School of Health Services, Atılım University, Ankara, Turkey, Aykut İlker Arslan, Department of Medical Laboratory, Vocational School of Health Services, Atılım University, Medicana International Ankara Hospital, Ankara, Turkey.
Bone mineral density · Irisin · Chronic kidney disease · Osteoporosis · Renal transplantation