Clinical and Laboratory Evaluation of Acute Pericarditis Associated with Antinuclear Antibodies Positivity

Dursun, Ali Doğan
Sarıçam, Ersin
Erdem, Hakan
Türkmen-Sarıyıldız, Gülçin
Özyer, Eşref Umut
Bozkurt, Engin
İlkay, Erdoğan
Cantekin, Ömer Faruk
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Current Vascular Pharmacology
Background: Up to 30% of patients with acute pericarditis develop recurrent pericarditis. Acute pericarditis may be a manifestation of an underlying systemic autoimmune disease. Therefore, we evaluated the characteristics of patients with acute pericarditis according to antinuclear antibodies (ANA) positivity/negativity. Methods: Participants with acute pericarditis and negative ANA (n=29), recurrent pericarditis with positive ANA (n=30) and healthy controls (n=11) were examined. The groups were compared using serum parameters (ANA, C-reactive protein, leucocyte count, erythrocyte sedimentation rate, total antioxidant status, nitric oxide (NO), and oxidative stress index (OSI)) and imaging techniques (electrocardiogram, echocardiography, cardiovascular magnetic resonance, and venous Doppler ultrasound). Results: In females, acute pericarditis associated with ANA occurred more frequently (p<0.001). ANApositive acute pericarditis had significantly lower NO and OSI (p<0.05 and p<0.001, respectively) and pericardial inflammation on magnetic resonance. We found a pulmonary embolism in one patient with positive ANA. Slow venous flow (SVF) occurred more often in acute pericarditis associated with ANA than in the ANA-negative group on venous ultrasound (p<0.05). The prevalence of positive ANAs was 1.6 times higher among SVF patients than in controls. Conclusion: This study suggests that acute pericarditis associated with ANA is more common in middle- aged females. SVF and lower oxidative stress tests were more common in patients with ANAassociated acute pericarditis. Acute pericarditis associated with ANA could be considered as a hypercoagulable state. Therefore, all newly diagnosed pericarditis patients (especially females) should be checked for ANA positivity. Awareness of this coexistence should be promptly addressed to establish management strategies.
Published by Current Vascular Pharmacology; DOI: 10.2174/1570161121666230131122649; Ali Dogan Dursun, Department of Physiology, Atılım University Medical School, Ankara, Turkey; Ersin SARICAM, Engin BOZKURT, Erdogan ILKAY, Department of Cardiology, Medicana International Ankara Hospital, Ankara, Turkey; Hakan ERDEM, 3Department of Rheumatology, Medicana International Ankara Hospital, Ankara, Turkey; Gülcin TURKMEN SARIYILDIZ, Department of General Surgery, Medicana International Ankara Hospital, Ankara, Turkey; Esref Umut OZYER, Department of Radiology, Medicana International Ankara Hospital, Ankara, Turkey; Ömer Faruk CANTEKİN, Faculty of Health Sciences, Department of Social Work, Gazi University, Ankara, Turkey.
Acute pericarditis, ANA positivity, female, oxidative stress